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07 December 2018 à 03:46

lxd123456, Friday 07 December 2018 à 03:46 | Quote

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SAN FRANCISCO? Jan. 1 (Xinhua) -- Jennifer Dionne? associate professor of materials science and engineering at Stanford University? has teamed up with Miriam B. Goodman? a professor of molecular and cellular physiology? to feed nanoparticles to millimeter-long worms.

When struck by a near-infrared laser? the particular nanoparticles glow and change color depending on the pressure around them? giving off real-time information about the forces they're undergoing while they're still inside the barely visible worms? known as Caenorhabditis elegans? according to a Stanford University news release on Sunday.

The ultimate goal of the work by the interdisciplinary partnership is to detect force in human cells? because as in humans? digestion in worms involves mechanical gnashing and shoving that can provide insight into how these nanoparticles register cellular force.

"Altered cellular-level forces underlie many disorders? including heart disease and cancer?" said Dionne. "This would be a nanoscale readout that you could use in vitro or in vivo to detect disease at a very early stage."

So far? Dionne's lab has made the nanoparticles? and Goodman's worms have eaten the high-tech snack and the researchers have taken static images of the nanoparticles inside the worms.

"The color that each nanoparticle emits changes from red to orange when there is a mechanical force on the order of nanonewtons to micronewtons? a force range thought to be very relevant for intercellular forces?" said Alice Lay? a graduate student in the Dionne lab who is leading the experiments.

The tiny size of the nanoparticles means they have the potential to produce extremely high-resolution force maps? providing a window into the push and pull of and by cells on a deeply subcellular level. Someday? these biocompatible nanoparticles could be ingested or injected into a person in a specific area? such as at a wound site or suspected tumor. Through reading the colors emitted by the nanoparticles? labs could create a force map that indicates the fine-scale activity of the cells around that area.

"Mechanical forces play a significant role in determining the fate and function of a cell or of an organ?" Dionne was quoted as saying in the release. "For example? every time our heart beats? our ears hear or a wound heals? cellular forces are involved."

After studying healthy worms? the team will introduce mutations into the mix to discern the role of gene expression on cellular forces. These mutations will allow the team to better understand digestive and related disorders? including acid reflux and hernia formation.

Director and actor George Clooney arrives at Omega's dinner party in Shanghai May 16 Nike Air Max Homme Soldes Pas Cher , 2014.

Actor George Clooney criticized Britain's Daily Mail on Wednesday for publishing what he called a "completely fabricated" story that said his future mother-in-law opposes his upcoming marriage to human rights lawyer Amal Alamuddin.

The Mail Online story posted on Monday said Alamuddin's mother was telling family in Beirut that she is not happy about the wedding for religious reasons and that her daughter could do better by marrying within the family's Druze religion.

"First of all, none of the story is factually true," Clooney, 53 Nike Air Max Femme Soldes Pas Cher , wrote in the newspaper USA Today.

"Amal's mother is not Druze. She has not been to Beirut since Amal and I have been dating and she is in no way against the marriage - but none of that is the issue," he added.

The issue, he said, is that the story said that because the Clooney nuptials will not be a Druze wedding Nike Air Max 2019 Soldes Pas Cher , Alamuddin could be cast out of the community. Women have been murdered for not abiding by the Druze religious rules, the Mail Online's story added.

"The irresponsibility in this day and age, to exploit religious differences where none exist is at the very least negligent and more appropriately dangerous," the Oscar-winning actor wrote.

Clooney Chaussure Nike Air Max Soldes Pas Cher , who does not usually respond to media reports about his private life, said he does not care about fabricated stories about where the wedding will take place or if he is running for public office.

"We have family members all over the world, and the idea that someone would inflame any part of that world for the sole reason of selling papers should be criminal," he wrote.

The Mail Online has since issued a statement apologizing to Clooney Nike Air Max Soldes Pas Cher Chine , his fiancée and her mother for any distress the story caused and said it has launched a full investigation.

"We have removed the article from our website and will be contacting Mr. Clooney's representatives to discuss giving him the opportunity to set the record straight," the statement said.

It added that the story was supplied by a trusted freelance journalist and was based on her contacts with senior members of the Lebanese community in Britain and Beirut.

In the USA Today report, Clooney said the fabricated story had been picked up by other news outlets, including Boston Nouvelle Nike Air Max Homme Soldes , The New York Daily News, Gulf News and Emirates 247. He added that facts make no difference to their stories.

"And when they put my family and my friends in harm's way, they cross far beyond just a laughable tabloid and into the arena of inciting violence," he wrote.

The Mail Online story was not published in the print edition. The newspaper followed it up Nouvelle Nike Air Max Femme Soldes , but with a different story. The print newspaper and the online edition are run separately.

Clooney, who won an Oscar for best supporting actor in 2006 for "Syriana," and shared the best picture award in 2013 for "Argo," has been dating Alamuddin since October Nouvelle Nike Air Max 2019 Soldes , according to media reports. News of their engagement was confirmed in April when Alamuddin's legal practice in London issued a statement congratulating the couple.


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